Immunotherapy in cancer, inflammatory and autoimmune diseases: restoring the delicate balance between protective immunity and self-damage

Published on 2016-10-06 14:28 CEST

Speaker: Dr. Julián Pardo

Date & location: Friday 7th October 2016, 12:30 - 00:00 (CEST). Sala de Conferencias, Edificio I+D+i, Campus Río Ebro


Immunotherapy in cancer, inflammatory and autoimmune diseases: restoring the delicate balance between protective immunity and self-damage

 

Immunotherapy is designed to harness the power of the host immune system to treat cancer, infection or inflammatory/autoimmune disorders. Inflammation is the master regulator of the protective immune response against cancer and infection. Ironically, most of the inflammatory pathways identified up-to-date also contributes to the pathology observed during inflammatory/autoimmune diseases as well as to the genesis and progression of cancer. Despite novel selective immunotherapy protocols have emerged in recent years to selectively enhance or reduce the immune response during cancer and autoimmune diseases, this dichotomy makes challenging to treat these disorders without predisposing to serious secondary effects.

Granzymes are a family of serine-proteases mainly expressed by cytotoxic CD8+ T and Natural Killer cells that traditionally were though to exert its biological functions by inducing cell death. Here we will present our last evidences gathered ex vivo and in vivo in several human and mouse models showing that while granzyme B is eminently a cytotoxic molecules that kill cancer cells, other granzymes like granzyme A seem to exclusively act as regulator of the generation of the inflammatory response during sepsis and autoimmunity. The potential mechanism involved in each pathology will be presented and the implications for the development of novel therapies reducing the risks of current immunosuppressive treatments will be discussed.

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